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Birth control patch and ring may raise blood clot risk





Birth control in the form of a vaginal ring or skin patch may bring a higher risk of blood clots than birth control pills, a new study from Denmark suggests.

In the study examining women over a 10-year period, a blood clot was twice as likely to appear in those who used a vaginal ring as in those who took birth control pills containing levonorgestrel, a synthetic form of the female hormone progesterone. And women who used a hormonal skin patch were 2.5 times more likely to have a blood clot than women taking those pills.

Birth control pills in general are known increase women's risk of blood clots, but the study adds to a growing body of evidence that some forms of hormonal birth control increase the risk of clots more than others do.

For any type of contraception that contains estrogen and progesterone, the risk of blood clots may have to do with the type of progesterone the pill contains, said Susan Jick, an epidemiologist at Boston University who has studied the safety of oral contraceptives.

Because the findings pertaining to the vaginal ring and patch are relatively new, more research is needed to confirm them, Jick said.

A female condom is a tube of soft plastic (polyurethane) with a closed end. Each end has a ring or rim. The ring at the closed end is inserted deep into the vaginaover the cervix, like a diaphragm, to hold the tube in place. The ring at the open end remains outside the opening of the vagina.
A diaphragm is a round, dome-shaped device made of rubber with a firm, flexible rim. It fits inside the vagina and covers the cervix, the opening of the uterus. It should always be used with a sperm-killing cream or jelly (spermicide).
A cervical cap is made of rubber and shaped like a large thimble. It fits tightly over the cervix and is used with a spermicide.
A contraceptive sponge contains a spermicide, nonoxynol-9, that is released over the 24 hours that the sponge may be left in the vagina. The sponge also blocks the cervix so sperm can't pass.
The cervical shield (such as Lea's Shield) is a new diaphragm-type device. The shield is made of silicone, so latex allergy is not a concern. The device comes in one size only, which makes the fitting process simpler.

However, experts emphasized that the risk of blood clots is very small from any type of hormonal birth control.

"What women really need to know about all of these methods is that, overall, their benefits overwhelmingly outweigh their risks," said Dr. Elizabeth Raymond, a senior medical associate at Gynuity Health Projects, an organization that aims to make birth control safer and more widely accessible. Hormonal birth control is highly effective in preventing pregnancy, which comes with its own risks, Raymond said, including an increased risk of blood clots.

Blood clot risk

In the new study, √ėjvind Lidegaard of the University of Copenhagen and colleagues analyzed information on more than 1.6 million women between ages 15 and 49 who were followed from 2001 to 2010.

During the study period, about 5,200 women had a blood clot.

Among women who were not using hormonal contraceptives, there were two cases of blood clots yearly per 10,000 women. For women taking oral contraception with levonorgestrel, the rate of incidence tripled to six cases yearly.

For women using vaginal rings, there were about eight cases yearly per 10,000 women, and among women using birth control patches, about 10 cases yearly per 10,000 women.

Women who used progestogen-only intrauterine devices, or progestogen-only birth control implants, did not have an increased risk of blood clots compared with women not using hormonal contraception.

The results held after the researchers took into account factors such as age that could affect a women's blood clot risk. However, the researchers were not able to account for everything that could affect the risk, such as weight, Raymond said.

Convenience factor

Last month the Food and Drug Administration said newer birth control pills such as Yaz and Yasmin that contain drospirenone, another form of progesterone, would carry revised labels indicating the pills may increase the risk of blood clots more than older types of birth control pills containing levonorgestrel.

Women have many considerations when they choose a birth control method, including the cost, availability and convenience. "Some women have trouble remembering to take pills," she added, and might be able to use a ring or patch more consistently.

Dr. Elizabeth Poynor, a gynecologist and pelvic surgeon at Lenox Hill Hospital in New York City, said women should speak with their health care provider about what form of hormonal contraception is best for them. Women with a family history of blood clots or stroke may be at increased risk for blood clots and should discuss this, Poynor said.
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